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Finally, the authors compared the IP accumulation and intracellular Ca2+ release signaling pathways in both WT and 5-HT2A–S314A expressed in intact cells. Three 5-HT2A receptor agonists [5-HT, DOI, and α-methylserotonin (AMS)] all showed increased efficacy and potency in phosphorylation-deficient 5-HT2A–S314A fibroblasts, compared with WT receptors,...